Denaturation transition of stretched DNA
نویسندگان
چکیده
منابع مشابه
Denaturation transition of stretched DNA.
In the last two decades, single-molecule force measurements using optical and magnetic tweezers and atomic force spectroscopy have dramatically expanded our knowledge of nucleic acids and proteins. These techniques characterize the force on a biomolecule required to produce a given molecular extension. When stretching long DNA molecules, the observed force-extension relationship exhibits a char...
متن کاملThe denaturation transition of DNA in mixed solvents.
The helix-to-coil denaturation transition in DNA has been investigated in mixed solvents at high concentration using ultraviolet light absorption spectroscopy and small-angle neutron scattering. Two solvents have been used: water and ethylene glycol. The "melting" transition temperature was found to be 94 degrees C for 4% mass fraction DNA/d-water and 38 degrees C for 4% mass fraction DNA/d-eth...
متن کاملDNA denaturation as a new kind of phase transition
Unbinding of a double-stranded DNA reduces to an unscreened long range interaction and maps on various problems. Heterogeneity renormalizes interaction. Renormalization is temperature dependent. At an unbinding transition it approaches critical dimensionality. This implies giant non-universal critical indexes and invalidity of the Gibbs distribution sufficiently close to the critical temperatur...
متن کاملWhy is the DNA denaturation transition first order?
We study a model for the denaturation transition of DNA in which the molecules are considered as being composed of a sequence of alternating bound segments and denaturated loops. We take into account the excluded-volume interactions between denaturated loops and the rest of the chain by exploiting recent results on scaling properties of polymer networks of arbitrary topology. The phase transiti...
متن کاملA Simple Model for the DNA Denaturation Transition
We study pairs of interacting self-avoiding walks {ω1,ω2} on the 3d simple cubic lattice. They have a common origin ω0 = ω 2 0, and are allowed to overlap only at the same monomer position along the chain: ωi 6= ω 2 j for i 6= j, while ω 1 i = ω 2 i is allowed. The latter overlaps are indeed favored by an energetic gain ǫ. This is inspired by a model introduced long ago by Poland and Sheraga [J...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2013
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20120298